A game changer is an event or decision that takes your life in a new direction and you will never be the same again. I have made decisions over the last 4 years that have been game changers. When I decided to quit my job at McKesson and leave Utah was a big game change. When I decided to move in with Terri to help her with childcare, that was another huge game changer. The news I received on November 23, 2011 was another big game changer. I have breast cancer.